Cellular senescence: when bad things happen to good cells
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death.
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Jul
09
Jul
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI).
09
Jul
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16(Ink4a) (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a distinctive secretory phenotype, prevents the prolife