10
Jul
Cellular senescence: when bad things happen to good cells
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death.... read more
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Sencell Therapeutics' main goal is to locate and clean the accumulation of senescence cells, a fact associated to aging.
Aging is the main cause of a large number of diseases
And senescent cells have been identified as one of the main causes of the development of ARD. The accumulation of these cells over time becomes a problem.
Accumulation of Senescent cells
Stimulation of immune system
Senescent cells clearance
Disease-free
ScientificEvidence
09
Jul
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI).... read more
09
Jul
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Cellular senescence, a stress-induced irreversible growth arrest often characterized by expression of p16(Ink4a) (encoded by the Ink4a/Arf locus, also... read more
08
Jul
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing rem... read more
Our Opinion
We expect to delay the onset of or cure aging-related diseases and thus improve the quality of life of old people, patients suffering from premature aging diseases and cancer patients who are treated with agents that induce premature senescence of tumor cells
Cayetano von KobbeCo-founder
This ambitious project addresses the potential treatment of several life-threatening diseases associated with aging and it is based on a completely novel approach to develop a vaccine against senescent cells.
Andoni CruzCo - Founder - Sencell Therapeutics
Senescent cells accumulate in the body as we age and it has been recently demonstrated that elimination of senescent cells by both genetic and pharmacological approaches delays the onset of aging-related diseases.
Roberto HernanCo - Founder - Sencell Therapeutics